Bioactive Small Molecules
Medchemexpress LLC Propofol-d17 β-D-glucuronide | 1683581-05-6 | 98.0% | 371.50 | C18H9D17O7 | 5 MG
Deuterium-labeled analog of propofol β-D-glucuronide supplied as a stable-isotope internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Supplied for research use only.
- High isotopic enrichment for accurate quantitation.
- Suitable as an internal standard for LC-MS, GC-MS, and NMR.
- Available in small milligram quantities for trace-level studies.
- High purity (98.0%) to minimize interfering impurities.
- Soluble in ethanol, DMF, and DMSO for analytical preparations.
Medchemexpress LLC Nimucitinib | 2740557-24-6 | 99.3% | 480.51 | 50 MG
Nimucitinib is a Janus kinase (JAK) inhibitor. This product is for research use only and not sold to patients.
- Cancer research
- Inflammation or immune system disease research
- Blood or cardio-cerebrovascular disease research
- Metabolic or endocrine disease research
- Digestive system disease research
- Urogenital disease research
- Musculoskeletal disease research
- Lipid metabolism research
- Autoimmune disease research
- Arthritis research
- JAK/STAT signaling studies
Medchemexpress LLC MAdCAM1 Human HEK2 100ug
Recombinant human MAdCAM-1 produced in HEK293 cells and supplied as a lyophilized, C-terminal His-tagged protein. The protein is characterized for low endotoxin and validated functional activity by cell adhesion assays, making it suitable for receptor binding, adhesion, and migration studies. Reconstitute and store according to the lot-specific certificate of analysis for optimal stability.
- Produced in HEK293 mammalian cells.
- C-terminal His tag facilitates detection and purification.
- Supplied lyophilized with lot-specific formulation details.
- Endotoxin <1 EU/μg for cell-based applications.
- Functional activity validated by cell adhesion assays (ED50 ~1.987 μg/mL).
- Suitable for receptor interaction, adhesion, and migration studies.
- Store frozen and aliquot to avoid repeated freeze-thaw cycles.
Cayman Chemical ANTIBODY HAPC-Chol 25mg
A cationic cholesterol; has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability; has been used to deliver siRNA into mice via intravenous injection, resulting in HAPC-chol accumulation in the lungs
Medchemexpress LLC MGD-28 | 2991818-13-2 | 99.7% | 595.67 | 100 MG
MGD-28 is a potent, orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM) in a dose-dependent manner. In addition, MGD-4 also degrades CK1α (DC50=7.8 nM). MGD-28 has antiproliferative activity and can be used in multiple myeloma research.
- Potent
- Orally active
- Cereblon (CRBN)-dependent IKAROS protein degrader
- Degrades IKZF1, IKZF2, and IKZF3 in a dose-dependent manner
- Degrades CK1α
- Antiproliferative activity
- Can be used in multiple myeloma research
Medchemexpress LLC Thalidomide-O-C6-COOH | 2169266-69-5 | MFCD32063464 | 99.3% | 402.40 g·mol⁻¹ | C20H22N2O7 | 5 MG
Thalidomide-O-C6-COOH is a thalidomide-based cereblon ligand-linker conjugate developed for use in targeted protein degradation (PROTAC) research. The molecule incorporates a thalidomide-derived cereblon-binding moiety tethered to a six-carbon linker ending in a carboxylic acid, enabling conjugation to target-binding ligands. It is supplied with high purity and characterized solubility and storage parameters for research use.
- Thalidomide-based cereblon ligand-linker conjugate suitable for PROTAC synthesis.
- Six-carbon linker terminating in a carboxylic acid for facile conjugation.
- Molecular weight 402.40 g·mol⁻¹ and formula C20H22N2O7.
- Purity 99.29% as supplied by the manufacturer.
- Soluble ≥ 100 mg/mL (248.51 mM) in DMSO.
- Supplied as an off-white to light yellow solid with recommended storage conditions.
Cayman Chemical ANTIBODY 12-SAHSA 1mg
A FAHFA consisting of stearic acid esterified to 12-hydroxy stearic acid
eMolecules 177931-17-8 | Medchem Express | Sauchinone | 5mg | 532149473 | HY-N0613 | MFCD08702698 | 356.374 | C20H20O6
ChemScene | tert-Butyl (4-iodobutyl)carbamate | 1g | 714103923 | CS-0137589 | 262278-40-0 | MFCD09951820 | 299.152 | C9H18INO2
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Medchemexpress LLC Benzamide, 4-(4-cyanophenoxy)- | 1042780-52-8 | 98.0% | 238.24 | 5 MG
PARP10-IN-2 is a potent mono-ADP-ribosyltransferase PARP10 inhibitor with an IC50 of 3.64 μM for human PARP10. It also shows inhibition on PARP2 and PARP15 with IC50s of 27 μM and 11 μM for human PARP2 and human PARP15, respectively.
- Potent mono-ADP-ribosyltransferase PARP10 inhibitor
- Inhibits PARP2 and PARP15
- Cytoprotective activity against human HeLa cells
Medchemexpress LLC S100P-IN-1 | 690991-06-1 | 99.8% | 440.40 | 25 MG
S100P-IN-1 is an S100P inhibitor with an IC50 of 22.7 nM. It demonstrates anti-metastatic effects on pancreatic cancer cells by blocking S100P binding to RAGE in a dose-dependent manner.
- Blocks S100P binding to RAGE in a dose-dependent manner.
- Exhibits S100P-specific inhibitory effects on cell invasion.
- Shows no significant cytotoxicity at 10 μM for 24 hours.
- Significantly inhibits invasion in BxPC-3 cells.
Medchemexpress LLC Rasagiline | 136236-51-6 | 99.9% | 171.24 | 250 MG
Rasagiline is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor. It also acts as a click chemistry reagent, featuring an Alkyne group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Highly potent selective irreversible mitochondrial monoamine oxidase inhibitor
- Inhibits MAO B activity with IC50 of 4.43 nM
- Inhibits MAO A activity with IC50 of 412 nM
- Functions as a click chemistry reagent
- Capable of copper-catalyzed azide-alkyne cycloaddition
- Demonstrates neuroprotective properties in transgenic models
- Increases cell proliferation rates in SH-SY5Y and 1242-MG cells
Selleck Chemical LLC IACS-010759 S8731-100MG
IACS-010759 (IACS-10759) is a potent and selective oxidative phosphorylation inhibitor (IC50 10 nM) that blocks cellular respiration through inhibition of complex I
TARGETMOL CHEMICALS INC SB-747651A DIHYDROCHLORI 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SB-747651A dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC 50 of 11 nM. SB-747651A dihydrochloride also inhibits PRK2 RSK1 p70S6K and ROCK-II. SB-747651A dihydrochloride has potential for inflammation research [1]. purity: 97%
Medchemexpress LLC L-Homocysteine | 6027-13-0 | 98.0% | 135.19 | 50 MG
L-Homocysteine is an amino acid with an L configuration, and an essential intermediate in the normal mammalian metabolism of methionine. It induces the upregulation of Cathepsin V, which mediates vascular endothelial inflammation in hyperhomocysteinaemia. This product is for research use only.
- Essential intermediate in methionine metabolism
- Induces upregulation of Cathepsin V
- Suitable for animal modeling to construct vascular endothelial inflammation models
Cayman Chemical nlfInavIrmesylate 5mg
An orally bioavailable inhibitor of the HIV-1 protease (Ki =2 nM) that is used in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection